What is ACEMg?
ACEMg is a patented formula of antioxidant micronutrient vitamins A, C and E and the vasodilator mineral Magnesium. ACEMg is made to the highest quality of potency, purity and guaranteed stability required of clinical medicine.

What does ACEMg do?
ACEMg helps protect and preserve hearing while your ears are exposed to intense sound and noise. ACEMg helps protect and preserve hearing throughout life. ACEMg is the result of three decades of neuroscience research that discovered oxidative stress caused by excess free radicals is the common root cause of acquired hearing loss. ACEMg eliminates the excess free radicals that cause the inner ear oxidative stress that damages hearing and causes hearing loss. ACEMg helps maintain normal inner ear blood flow, blocking the ‘choke-and-release’ caused by the vasoconstrictor isoprostane 8-iso prostaglandin F2a.

Will ACEMg bring back my hearing?
ACEMg is designed to protect and preserve the hearing you have. ACEMg will not bring back hearing you have lost. Medical science is working on hearing regeneration drugs and gene therapies that may be available someday. Today, based on all the evidence we have, we believe ACEMg is the best option available to preserve your hearing by helping hearing cells keep working the way they’re supposed to work.

Will I experience a difference in my hearing? How can I tell it’s working?
Hearing loss is affected by age, lifestyle factors like sound and noise exposure, life quality factors like nutrition, and genetics. The availability of ACEMg is an important milestone that opens the next chapter in our mission to collect data on hearing loss and hearing preservation, but today we don’t have enough data to provide an answer. Taking ACEMg is the only way for you to tell.

Based on anecdotal data collected since early 2015, we suggest taking ACEMg for 4 weeks, then stop for two weeks and see if you notice differences. We welcome your informal feedback if you want to share, at support@hearinghealthscience.com. Please sign up for the newsletter to be informed about the ACEMg real world studies, designed to provide clinical quality epidemiological research data from the general population.

What we know today is that ACEMg helps eliminate inner ear oxidative stress and maintain good inner ear blood flow so your ears function normally and stay healthy. If your ears are under a high degree of oxidative stress, you may perceive differences that accompany reduction of that stress. Anecdotal reports include increased hearing acuity and reduction of tinnitus symptoms. We cannot and do not claim you will perceive differences in your hearing or tinnitus symptoms.

Is there a connection between hearing loss from aging and hearing loss from exposure to intense sound and noise?

The root cause of age-related hearing loss (ARHL) and so-called noise-induced hearing loss (NIHL) is the same: oxidative stress caused by excess inner ear free radicals. Recent preclinical studies created new understanding about the linkages, demonstrating that hearing physiology and biochemistry are robust. Short term exposure to about 100dB doesn’t seem to bother relatively young ears. That’s good news. The bad news is that regular and frequent exposure to intense levels of sound and noise accelerates hearing loss, regardless of its source. Data show that by protecting hearing cells from noise exposure, ACEMg also reduces ARHL.

What if I wear hearing aids or have cochlear implants?
ACEMg can help. It can’t hurt. Hearing aids, cochlear implant devices, earbuds and headphones are electronic devices that amplify sound in the ear. These devices have become a permanent part of modern life. All can create inner ear oxidative stress by placing extra energy demands on inner ear hearing cells.

When do I take it?
Long term exposure to unsafe levels of intense sound and noise causes damage and death of hearing cells, resulting in permanent hearing loss. This is the fastest growing cause of hearing loss today.

Most hearing loss is slow and progressive, so you’re unlikely to notice small changes until they become big changes. So-called noise induced hearing loss (NIHL) accounts for about 25% of all hearing loss. It’s a major issue for younger people.

ACEMg is formulated to help preserve and protect hearing cells in situations of intense sound and noise. We suggest taking ACEMg daily whenever you are exposed to intense sound and noise. We offer a 1-week Festival Pack of softgel capsules for those who periodically enjoy loud entertainment and live music festivals.

We offer a 4-week pack of softgels for those who are regularly and frequently exposed to intense levels of sound and noise and want to use ACEMg to help maintain hearing health over the long term.

Is it safe? Can you reassure parents that their kids are safe taking this?

Yes, ACEMg is safe. The safety of micronutrient supplements – vitamins and minerals – has been researched since the first vitamins were discovered about 100 years ago. The dose strength is suitable for people in their middle teenage years and older. Young children need a lower dose, which we have developed for physicians treating children with genetic hearing loss. We are developing lower dose strengths of ACEMg for the general public. 

I take vitamins already. Will that do the trick?

Possibly but unlikely. Many people already take antioxidant vitamin supplements to help eliminate oxidative stress. ACEMg is a scientifically balanced, potent dose of antioxidants and a vasodilator mineral (ACEMg, say ‘Ace Mag’) designed to relieve the oxidative stress that damages hearing and causes hearing loss, helping hearing cells to continue functioning normally while they are exposed to intense sound and noise.

The dose is much higher than what is available in most multivitamin supplements, but still within the safe upper limit of daily intake, even if you already take a multivitamin supplement.

ACEMg components are absorbed in the circulating bloodstream and distributed throughout the body. They may act anywhere, but are specifically effective in inner ear cells, the site of massive production of antioxidants and vasoconstriction that happens with exposure to intense sound and noise. 

Why is ACEMg made as a drug?

Vitamins and minerals are regulated as nutritional supplements, but they can also be used as medicines to treat metabolic disorders and disease. Hearing loss is a metabolic disorder. ACEMg is made as a drug so it can be used as a clinical trials medicine (CTM) in randomized clinical trials (RCT). This is the gold standard medical research method using a placebo and active. ACEMg has been a CTM since 2012.

Metabolic diseases include night blindness, beriberi, scurvy and pellagra. They are caused by vitamin deficiency and can be treated effectively with vitamins. Although hearing loss is not a fatal metabolic disorder, it is a major public health problem. Hearing loss has serious negative effects on social vitality and increases the risks of cognitive dysfunction and brain disease like Alzheimer’s. Hundreds of millions suffer and more than a billion people are at risk, mainly young people.

For all these reasons, Hearing Health Science has an ongoing, comprehensive clinical and epidemiological research program for ACEMg, aiming to fully understand its efficacy and effectiveness to treat hearing loss caused by oxidative stress-induced inner ear metabolic disorder.

ACEMg complies with the exceedingly rigorous standards of RCT medical research, including pharmaceutical manufacturing of active and placebo clinical trial medicines and regulatory compliance. These standards require drug agency disclosure of all manufacturing details and certificates of analysis of each ingredient to guarantee levels of purity, potency and stability that are far more rigorous than required for nutritional supplements.

What about side effects?

Micronutrients – vitamins and minerals – are generally regarded as safe (GRAS) by the EFSA (EU) and the FDA (USA).  There are virtually no side effects from normal intake of micronutrients, but like any food, side effects are possible if you consume too much. The initial daily dose strength of ACEMg is formulated for those requiring protection from exposure to intense sound levels and noise. We recommend not exceeding the recommended dose. Younger children require a smaller dose. High doses of magnesium can cause loose stools. Heavy smokers should consult their physician about taking vitamin E.

We know that insufficient intake of micronutrients can cause metabolic stress disorders, some  quite serious. Now we have evidence that acquired hearing loss from noise exposure and aging are also metabolic stress disorders that can be mitigated by micronutrient supplementation; specifically, the ACEMg micronutrient formula.

What is ACEMg? Is it a drug?

ACEMg is a safe, patented, scientifically validated formula of vitamins and a mineral. It is not a drug and does not require a medical prescription. All the ingredients in ACEMg occur in nature. ACEMg is produced to pharmaceutical standards, as you would a drug, but ACEMg is a formula of micronutrients, a preventive care therapeutic closer to a vaccine that prevents a disease than a prescription pharmaceutical that treats a disease.

Why do you say ACEMg is the product of pioneering medical research?

Hearing preservation research is young science. In the last thirty years medical researchers developed and accepted the biochemical concept of hearing loss. The field is in beginning stages of the next generation of hearing preservation. A large part of the credit goes to the pioneering discoveries from research started in the 1980s by Hearing Health Science founder Dr. J. M. Miller and his University of Michigan Medical School lab team. Their work changed the way medical science understands hearing loss and created the possibility of new solutions.

Over the past decade new potential therapeutic treatments for hearing preservation have started emerging from this new understanding. Many drugs are in development. ACEMg is a safe micronutrient cocktail, the first non-prescription treatment of this new direction in auditory neuroscience research to reach the general public and begin solving the problem for everyone.

Learn more about the research here.

How do you take ACEMg, when and how often?

The dose strength of the initial release of ACEMg is intended for people who are regularly and frequently exposed to damaging levels of intense sound and noise. Investigations show it can take inner ear cells several days to recover from exposure to intense sound or noise.

Our guidance is to take it when you need it, especially when you’re going to be exposed to loud sound. We suggest taking ACEMg the day before or the day of events like watching Max Verstappen race Formula I, going to a dance music festival or spending the night clubbing, for example. ACEMg softgels are packaged in seven-day packets to encourage full recovery in the days following intense sound or noise exposure.

Are you medicalizing a problem that should be prevented by behavioral changes rather than getting everyone to take pills?

Changing behavior to reduce risk is always best. But people are people. We often like to enjoy things that also pose a risk, like loud music. Currently we may wear earplugs or turn down the volume a bit. Now we have another option to help maintain healthy hearing. Most people in The Netherlands ride bikes without a helmet. This changes when we get on a racing or mountain bike. The risks are larger, so we take more precautions to protect ourselves from a serious head injury. It’s up to you.

What about when I am listening to music on headphones?

Depends on how long you listen and the volume. ACEMg can help and can’t hurt, so if you use any personal listening device for long periods or at loud volumes – earbuds, headphones, even hearing aids or cochlear implants – you might want to consider it. But please think of ACEMg as insurance and not a free pass to take risks. Consume sound like alcohol: responsibly. When you drive a car, wearing a seatbelt makes you safer, but it isn’t a stimulus to drive recklessly.

I read somewhere that hearing loss is caused by sound literally bursting or breaking your eardrums. You are saying that’s not true. Are other experts wrong?

That can be true. A loud enough sound like gunfire or an explosion can certainly cause blast trauma injury – permanent, irreparable damage to the delicate physical structures of your ears. About one-third of active duty soldiers are permanently hearing impaired from blast trauma. However, ninety percent of hearing loss is not caused by blast trauma, but by a complexity of environmental, epigenetic and genetic factors. Although we call this hearing loss, sensorineural hearing loss is the accurate medical term for the most common forms of hearing loss. It can take years or decades for progressive hearing loss to become profound hearing loss or deafness, so most people think hearing loss is inevitable and don’t think of it as an ongoing metabolic disorder or metabolic disease process.

Although hearing loss is a part of the natural aging process, it is caused by ongoing interactions of factors including environmental exposure, nutrition, genetics and aging. We focus on environmental and lifestyle factors because they can accelerate the process.When people begin to notice hearing loss they tend to think it is caused by listening to very loud music when they were younger adults.  That is partially true. Today hearing loss is happening to more people earlier in life than ever before. Urban life is increasingly noisy and personal listening devices have become ubiquitous. 

Will there be other preventive treatments?

Many alternative hearing loss treatments are in development. Virtually all are pharmaceutical drug discovery initiatives using the clinical medicine development pathway. They will require drug agency approvals, prescription and physician monitoring. ACEMg is a safe micronutrient cocktail, so it does not require a prescription and can be used by everyone (Children require a smaller dose. Heavy smokers are advised to consult a physician before taking antioxidants).

Can I throw the earplugs away and turn up the volume?

That is not something we would advise. ACEMg is complementary to all devices used for hearing protection (earplugs and filters), personal listening (earbuds and headphones) and hearing assistance (hearing aids and cochlear implants). ACEMg is not intended to replace them, nor is it a free pass or an excuse to take risks with your hearing. Wearing a seatbelt makes driving a car safer, but is not a stimulus to drive recklessly.

Government has ordered the volume to be reduced at festivals. Is that the answer?

Governments are responsible for public health and safety. They are battling the problem of preventing hearing loss by using the two options they have – earplugs and volume control. These options are only modestly successful. Neither can be expected to solve the problem. Turning down the volume at festivals is good and bad. Low-volume events cause less hearing damage, but they’re also less fun, so people leave early or choose not to attend, which reduces economic and cultural value. We are engaged with many stakeholders to introduce ACEMg as the third way.

Is it normal that I’m losing my hearing as I get older? Is it related to hearing damage from listening to loud music when I was younger?

Age-related hearing loss (ARHL) or presbycusis is part of aging. However, ARHL and noise-induced hearing loss, or NIHL, are linked. Listening to loud music contributes to noise-induced hearing loss, and NIHL contributes between 25 and 50% of the burden of ARHL. In other words, NIHL speeds up the onset of ARHL and contributes to making it worse. But listening to loud music is not the only cause of NIHL.

Our urban environments are increasingly noisy with a rapidly increasing percentage of the world’s population living in them. In 1800, only 3 percent of the world’s population lived in urban centers. By 1900, almost 14 percent lived in urban centers, 30 percent by 1950.

In 2008, for the first time, the world’s population was evenly split between urban and rural areas. There were more than 400 cities over 1 million population and 19 over 10 million. More developed nations were about 74 percent urban, while 44 percent of residents of less developed countries lived in urban areas. Now urbanization is occurring more rapidly in many less developed countries.

It is expected that 70 percent of the world population will be urban by 2050, and that most urban growth will occur in less developed countries. All of this means that an increasing percentage of the world’s population will suffer hearing loss in the coming years and decades. Hearing loss is already happening to more people earlier in life. 

Government has ordered the volume to be reduced at festivals. Is that the answer?

Governments are responsible for public health and safety. They are battling the problem of preventing hearing loss by using the two options they have – earplugs and volume control. These options are only modestly successful. Neither can be expected to solve the problem. Turning down the volume at festivals is good and bad. Low-volume events cause less hearing damage, but they’re also less fun, so people leave early or choose not to attend, which reduces economic and cultural value. We are engaged with many stakeholders to introduce ACEMg as the third way.

So the hearing loss problem is bigger than music. How big is the problem?

Very big.

Hearing health is a foundation of wellbeing and social progress. Hearing affects quality of life and opportunity for everyone. Hearing loss causes social isolation, a significant risk factor for Alzheimer’s and other brain diseases. About 80% of those with hearing loss suffer tinnitus. There is no cure.

Hearing loss is unequally distributed around the globe. 5.3% of the population suffers disabling hearing loss with 89% living in low- or middle-income countries (LMIC), 11% in high-income countries (HIC).  Moderate hearing loss is more common, affecting ability to understand speech, for example. Reliable current data is hard to find; it is fair to say that about 10% of the world population suffers. An additional 1.1 billion worldwide are at risk for NIHL, aggravated by digital technologies. Numbers are expected to rise substantially with the aging of the world population. This makes hearing loss the world’s largest unmet medical need, the only non-fatal disease among the world’s top five global health problems.

We believe prevention is the cure.

Many companies claim all sorts of benefits from vitamin supplements that turn out untrue or cannot be proved. Why should I believe you?

The first vitamins were discovered about a hundred years ago. The term “vitamine” was first used in 1912. During the first half of the 20th century we learned that several fatal diseases common in Europe, North America and Asia are nutritional deficiency diseases. These diseases are initiated by metabolic stress caused by lack of certain vitamins and minerals.

Some nutritional deficiency diseases have been eradicated, some persist today. Scurvy is caused by a lack of vitamin C. Rickets is caused primarily by a lack of vitamin D. Nyctalopia, or night blindness, is caused by vitamin A deficiency. Pellagra is caused by a lack of vitamin B3 (niacin). Beriberi is caused by a lack of thiamine (vitamin B1).

The umbrella term for vitamins and minerals is“micronutrient”.  As scientists discovered the essential role of micronutrients in maintaining health and preventing disease, manufacturers started adding them to mass produced food products, promoting these products as healthier than normal food. Ironically, micronutrient supplementation of many mass produced food products is necessary to restore the natural micronutrients destroyed in making the products.

There were no regulations to stop them from making unproved claims in the early days of mass produced food products. Claims were often dubious, and the additives were sometimes dangerous. Ultimately, government agencies stepped in to regulate micronutrients, along with the claims manufacturers are allowed to make about the products that contain them. But some problems persist. 

Our understanding of the complex connections between nutrition, metabolism, health and disease is constantly evolving with ongoing scientific investigations. Today, most people know micronutrients are essential to proper nutrition and some micronutrients have specific health benefits. Many choose to take multivitamin supplements to help preserve and promote their health. Nearly half the population of developed nations take vitamin supplements.

 ACEMg is a precise combination of micronutrients that have been demonstrated to have a synergistic effect on hearing preservation when taken together. Lab studies demonstrated ACEMg – trademarked ACEMg – can protect the inner ear by 30dB or more,  a remarkable six doublings or more in sound energy. The findings have been replicated by other leading university research labs. Our findings are the basis for five issued patents and three patents pending.

HHS understands the underlying biochemical mechanism of action that generates these findings. HHS is at the leading edge of demonstrating the health benefits of the safe ACEMg micronutrient cocktail in the general population. But at this point we cannot and will not make claims that ACEMg will work for every person, nor can efficacy be measured individually.

However, we understand each person wants to know if ACEMg is working for them, and want to know too. That’s why we’re pairing ACEMg with a free app and starting the long term Help Us Help You initiative. Much more to come on that.

Learn more about the research here.

Will ACEMg restore hearing?

No. Restoring hearing requires therapeutics that regenerate hearing cells. This is a long term direction for hearing research by others, not HHS at the moment. Lower vertebrates – examples include birds and fish – have a gene that enables hearing cells to regenerate. Higher level vertebrates – mammals – have that gene, but developed a series of biochemical mechanisms that switches it off, preventing that gene from activating. Consequently, hearing cells in humans do not regenerate. 

Hearing regeneration science has been ongoing since the mid 1980s in parallel to our work. Yehoash Raphael, a University of Michigan colleague, was among the first to show some of the fundamental mechanisms by which hearing regeneration might occur.

First, Dr. Raphael destroyed hearing cells, then introduced the gene ATHOL to induce regeneration. Dr. Stephan Hiller from Harvard is engaged with this work at Stanford. Dr. Ed Rubel is at University of Washington. Dr. Albert Edge is at Harvard. The NIH is also working on this. Audion Therapeutics is working on hearing regeneration in the Netherlands. There are others. 

Recent published evidence indicates that ACEMg can reverse hearing loss to a limited extent and in the specific condition of the Connexion 26 genetic defect. This does not mean that it is possible for ACEMg to regenerate hearing. It is evidence that we have accomplished our primary objective of protecting hearing cells and preventing cell death as a consequence of oxidative stress caused by excess free radicals, including oxidative stress from a genetic defect known to cause millions of cases of progressive hearing loss.

Does Hearing Health Science have a social mission, or are you just in this for the money?

The company’s core purpose is auditory neuroscience medical research conducted in the public interest. The research started in 1985, a quarter of century before the company was founded in 2010. The company is a natural byproduct of that research. We haven’t lost sight of our core purpose: HHS is a public benefit neuroscience company.

We’re on a mission to preserve hearing for everyone. We make money so we can continue doing research in the public interest, cooperating with academic scientists, government agencies and nonprofit hearing advocacy initiatives to pursue our goal of reducing hearing loss and preventing people from becoming deaf. We are a proud partner of the Nationale Hoor Stichting (the Netherlands hearing foundation), for example.

Our business model integrates for-profit and non-profit activities into one entity. We allocate money from ACEMg sales to two long term initiatives: i) advance hearing preservation research, and ii) provide ACEMg to people who need it but cannot afford it or need help accessing it.

Significant levels of government grant funding from the US National Institutes of Health and the European Commission Public Health Programme shows HHS is not playing this game on our own, nor is this about us; it is about solving the growing problem of hearing loss.

HHS has had ongoing support from government and private investors and on both sides of the Atlantic to develop the solution and bring it to the retail consumer market. Our next phase involves three public benefit initiatives running in parallel, collectively known as our  ‘Help Us Help You’ public benefit initiatives. 

The chance of success preserving hearing increases as more customers, partners and organizations join these initiatives.

Equal access. A share of revenue from every sale of ACEMg is redirected to the distribution of ACEMg without charge to those who need it and cannot access it or afford it.

Research. A share of revenue is redirected to ongoing medical research with academic partners to improve understanding of free radicals in inner ear pathology and develop new products and services. 

Citizen science. The ACEMg real world studies are long term epidemiological studies engaging the general public in assessing efficacy of ACEMg. 

For customers, this means testing your hearing accurately; comparing your hearing to the world, comparing your environment to the world; knowing how loud is it where you are; and monitoring your exposure so you know how long is it safe to listen. 

For HHS, this means developing a platform for collecting and expanding the largest data set on hearing; sharing data with accredited academic partners and public agencies; confirming expectations and analyzing efficacy; creating ever-better informed customers; mapping sound around the world – think Google maps for sound. 

If ACEMg already works, why do you need to continue testing it?

We are most glad to be asked this question. Think of our work as a road trip. HHS founder Dr. Joe Miller and his University of Michigan Medical School team had their ultimate destination clearly in mind from the start in 1985.

The first step was to identify the root cause of hearing loss. They did that in ten years.

1996, that started to develop a solution. Their goal was to find a safe, affordable non-prescription treatment that would have the world impact required to solve the problem.

The second step was to invent the solution. Done in eleven years. The third step was to get the solution from the lab to the market. Done in ten years.

The next part of the road trip is collecting data from the widespread use of ACEMg in the general population in an epidemiological study program.

Hearing loss is a complex disease with environmental and genetic factors that vary widely. These factors present big challenges to researchers studying hearing loss. Our studies, the first of their kind, have taken years to plan, will start in 2016 and can scale globally because the studies happen on an app.

Our ultimate goal is for anyone anywhere to participate. We expect experience with ACEMg to vary with age, genetics, nutrition, environmental factors like frequency, duration and exposure to sound and noise, lifestyle and geography.

What is still to be learned about ACEMg? What is your research plan?

Hearing preservation research is young science. ACEMg research is divided into three parts: preclinical research; clinical research; and epidemiological or real world research. Research is ongoing in all three categories.

Preclinical Research

Preclinical research helps define and add understanding to the underlying mechanisms of hearing loss and the mechanisms of action of the ACEMg intervention. For example, recent studies created new understanding about the linkages between noise-induced hearing loss (NIHL) and age-related hearing loss (ARHL). Data demonstrate that hearing physiology and biochemistry are robust. Short term exposure to about 100dB doesn’t seem to bother relatively young ears. That’s good news. The bad news is that regular and frequent exposure to intense levels of sound and noise accelerates hearing loss, regardless of its source.

Data show that by protecting hearing cells from noise exposure ACEMg also reduces ARHL. These findings provide the underlying rationale for clinical and real world epidemiological studies.

Clinical Research

Clinical research is drug research; randomized, controlled trials (RCT) conducted using double-blind, placebo-controlled methods. In RCT trials, neither the person giving the medicine nor the person getting it knows if they are getting the active or placebo.

ACEMg is manufactured as an active and placebo clinical trial medicine (CTM) and approved by drug regulatory agencies for use in clinical trials in the EU and USA.

The ACEMg clinical trial program includes testing ACEMg to preserve hearing in cochlear implant patients; preserving hearing in children with the Connexin 26 gene defect; blocking hearing loss caused by the ototoxic side effect of gentamicin antibiotics; blocking the ototoxic side effect of cytomegalovirus. The clinical trials program continues to expand with new preclinical discoveries.

Epidemiological Research

Epidemiological research is real world research. It is the most potentially impactful, but complex. Our real world research is citizen science –  scientists partnering with citizens for public good. 

It is best to use epidemiological or real world research to study age-related hearing loss (ARHL) and noise-induced hearing loss (NIHL) because they are linked. Both typically develop over many years or decades, and are influenced by environmental, genetic, nutritional and lifestyle factors.

The ACEMg real world studies are designed to assess efficacy among a broad range of populations globally.

Long term studies of ACEMg are planned because ongoing use of ACEMg from early in life has been shown to delay the onset of ARHL. ACEMg reduces ARHL in subjects exposed to a moderate level of noise. It is possible that adding ACEMg to diet to delay and reduce ARHL may be like adding fluoride to toothpaste to reduce cavities.

Real world studies with people at high risk for NIHL and people who suffer tinnitus are proceeding, because  data demonstrate that ACEMg reduces NIHL in situations of continuous exposure of noise, extending the original work showing efficacy with a single noise exposure. 

The goal of the ACEMg research program is to generate human data to support future health claims about ACEMg

  • Maintains normal hearing longer and delays the onset of presbycusis – age-related hearing loss (ARHL)

  • Reduces temporary hearing loss (known as temporary threshold shift or TTS)

  • Reduces permanent hearing loss (known as permanent threshold shift or PTS)

  • Reduces tinnitus symptoms for those who suffer

  • Prevents tinnitus by preventing the hearing loss that causes it

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